Impact of RT-PCR Test False-Negative Results for SARS-CoV-2 Surveillance in Mexico
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Abstract
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SciScore for 10.1101/2020.09.17.20197038: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
NIH rigor criteria are not applicable to paper type.Table 2: Resources
No key resources detected.
Results from OddPub: Thank you for sharing your code and data.
Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:This approach as applied for Mexico has several limitations. As only a few symptomatic people are tested we cannot estimate the corrected number of cases among the total population. This would require a vastly higher number of tests. Thus, there should be caution when interpreting our results. Our estimation presents a limited view of how much more cases there are, and thus do not represent the actual number of cases in the country; in …
SciScore for 10.1101/2020.09.17.20197038: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
NIH rigor criteria are not applicable to paper type.Table 2: Resources
No key resources detected.
Results from OddPub: Thank you for sharing your code and data.
Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:This approach as applied for Mexico has several limitations. As only a few symptomatic people are tested we cannot estimate the corrected number of cases among the total population. This would require a vastly higher number of tests. Thus, there should be caution when interpreting our results. Our estimation presents a limited view of how much more cases there are, and thus do not represent the actual number of cases in the country; in any case our corrected estimates are in the conservative side.14, 28, 29 We assumed that the date on which the information was captured in the system is the same on which the sample was procured, but there might be a small-time lag between one and another. We also identified limitations related to the diagnostic tests. For instance, there is a wide catalog of SARS-Cov-2 RT-PCR tests currently used in our country. Even if all of them have to be approved by the Institute of Diagnosis and Epidemiological Reference (INDRE) for surveillance purposes and all must comply with the Berlin protocol, we do not know how they compare to each other, and variation in diagnostic accuracy probably exists. We also do not have information on the anatomical test site, be it nasal or oropharyngeal swab, saliva or bronchoscopy sample, which could affect test sensitivity. We do not account for severity of the clinical picture on the test sensitivity. Sensitivity of the test in patients who develop pneumonia and /or critical illness could be higher than in those with ...
Results from TrialIdentifier: No clinical trial numbers were referenced.
Results from Barzooka: We did not find any issues relating to the usage of bar graphs.
Results from JetFighter: We did not find any issues relating to colormaps.
Results from rtransparent:- Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
- Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
- No protocol registration statement was detected.
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