Antiviral Combination Clinically Better Than Standard Therapy in Severe but Not in Non-Severe COVID-19
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SciScore for 10.1101/2021.06.06.21258091: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Ethics IRB: STUDY SETTINGS, DESIGN, AND POPULATION: The study was a single-center, open-label, parallel-arm, stratified randomized controlled trial conducted at All India Institute of Medical Sciences (AIIMS), Rishikesh, Uttarakhand, India between March 2020 to October 2020 after obtaining approval of Institutional Ethics Committee. Sex as a biological variable Exclusion criteria included: patients on medications which were contraindicated with lopinavir/ritonavir, hydroxychloroquine/chloroquine, or ribavirin; patients taking lopinavir-ritonavir based anti-retroviral therapy or on hydroxychloroquine/chloroquine or ribavirin; known allergic reactions to any of the drugs used in the treatment arms; … SciScore for 10.1101/2021.06.06.21258091: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Ethics IRB: STUDY SETTINGS, DESIGN, AND POPULATION: The study was a single-center, open-label, parallel-arm, stratified randomized controlled trial conducted at All India Institute of Medical Sciences (AIIMS), Rishikesh, Uttarakhand, India between March 2020 to October 2020 after obtaining approval of Institutional Ethics Committee. Sex as a biological variable Exclusion criteria included: patients on medications which were contraindicated with lopinavir/ritonavir, hydroxychloroquine/chloroquine, or ribavirin; patients taking lopinavir-ritonavir based anti-retroviral therapy or on hydroxychloroquine/chloroquine or ribavirin; known allergic reactions to any of the drugs used in the treatment arms; inability to take oral medications (lopinavir-ritonavir, hydroxychloroquine/ chloroquine, ribavirin); pregnant or lactating females; patients who had received any of the experimental therapies for 2019-nCoV (off-label, compassionate use, or trial-related) within 30 days before participation in the present study. Randomization STUDY SETTINGS, DESIGN, AND POPULATION: The study was a single-center, open-label, parallel-arm, stratified randomized controlled trial conducted at All India Institute of Medical Sciences (AIIMS), Rishikesh, Uttarakhand, India between March 2020 to October 2020 after obtaining approval of Institutional Ethics Committee. Blinding not detected. Power Analysis not detected. Table 2: Resources
No key resources detected.
Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).
Results from LimitationRecognizer: An explicit section about the limitations of the techniques employed in this study was not found. We encourage authors to address study limitations.Results from TrialIdentifier: No clinical trial numbers were referenced.
Results from Barzooka: We did not find any issues relating to the usage of bar graphs.
Results from JetFighter: We did not find any issues relating to colormaps.
Results from rtransparent:- Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
- Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
- No protocol registration statement was detected.
Results from scite Reference Check: We found no unreliable references.
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