Total salivary proteins in the oral cavity of healthy people

Objectives The objective of this work was to determine the number and identity of the total proteins present in the saliva of healthy people. Methods For its development, this work used literature review and bioinformatics tools. The literature review was conducted using various sources, including PubMed, Elsevier, ScienceDirect, Springer, and Wiley Online Library, as well as bioinformatics tools such as UNIPROT, The Human Protein Atlas, and Expasy-PROSITE, to identify and characterize proteins present in the oral cavities of healthy people. Results After conducting a bibliographic search and using bioinformatics tools, we obtained up to 1,720 proteins. There were 162 proteins obtained from the literature review, and the rest were obtained using bioinformatics sites. In other words, High-resolution experiments, such as microarrays or transcriptomes, have detected the expression of between 6000 and more than 30000 genes in the salivary glands. Conclusions It is difficult to identify all proteins present in the oral cavity; however, several authors have sought to elucidate their identities and functions, although the mechanisms that regulate the presence of specific proteins in the oral cavity remain unknown.