Study The Effect of Ascorbic Acid on Oxidative Stress of Rabbits Blood Samples Dosed with AL Nps, BCG Vaccine, and Polio Vaccine

Important findings were found in this study about vaccines in general and their oxidative effects on rabbits because the companies that make them add substances that, when taken, cause serious symptoms. This is what we observed in the vaccines used to combat the coronavirus pandemic. Analyses of blood samples from rabbits exposed to several vaccines (BCG and polio) and to Alum nanoparticles (AL NPs), one of the vaccine components, were conducted using a cyclic voltammetric approach in electrochemistry. The appearance of oxidation peaks was observed in each of the blood samples of rabbits exposed to AL NPs, as well as the vaccines. The blood samples were treated with ascorbic acid (AA), which gave successful results by inhibiting the oxidation peaks and reducing them from the blood, Therefore the use of ascorbic acid as an antioxidant agent, which considered as a response to its interferences with different vaccines in the blood medium. Oxidative stress induction by ALNPs and vaccine was indicated by significantly (P < 0.05) increase in superoxide dismutase and catalase activities. These changes were lowered to approximately normal level when after using vitamin C combination during these oxidative stresses. Thus, advice can be given to use ascorbic acid with all vaccines in order to avoid the risks resulting from the different vaccines.