Pancreatic Malakoplakia in a Patient with Chronic Pancreatitis: A Case Report

Introduction : Malakoplakia is a granulomatous disease that most frequently involves the genitourinary system and is commonly associated with immunosuppressed patients. However, these lesions can affect other organs, including the pancreas. Its presentation can mimic other pancreatic pathologies, such as neoplasms or chronic pancreatitis, making its diagnosis challenging. Early and precise diagnosis of the disease may avoid unnecessary surgery and improve outcomes. Patient presentation : A 39-year-old woman who presented with abdominal pain underwent a distal pancreatectomy and splenectomy, and the pathology revealed rare malakoplakia in the context of chronic pancreatitis. Notably, the patient had no immunosuppression or infection. Conclusion : We report a rare case of pancreatic malakoplakia in a patient with no immunosuppression or infection to raise awareness of this condition and further reviewing findings from previously reported cases of pancreatic malakoplakia in the literature.