Molecular Mechanistic Insights of Pancharavinda Choornam in Cognitive Enhancement and Comorbidity Management in Neurodegenerative Disease
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Background: Pancharavinda Choornam is an Ashtavaidya formulation traditionally recognized for its Medhya (cognitive enhancing) properties and is used in the management of neuropsychiatric comorbidities such as insomnia, anxiety, and depression associated with neurodegenerative disorders. Aim of the study: This study aimed to elucidate the mechanism of action of Pancharavinda Choornam in cognitive enhancement and comorbidity management in neurodegenerative conditions using a network pharmacology approach. Materials and methods: In vitro antioxidant assays were performed to assess antioxidant potential, followed by network pharmacology analysis to identify compound–target interactions and multitarget pathway modulation. Results: The formulation demonstrated significant antioxidant activity and modulated key genes, including APP (amyloid precursor protein), TAU (microtubule associated protein tau), MAOA (monoamine oxidase A ), BACE (beta site amyloid precursor protein–cleaving enzyme 1), PSEN (presenilin), and PSEN1 (presenilin 1) involved in neurodegenerative pathways. Conclusion: Pancharavinda Choornam exhibits multitarget therapeutic potential and may serve as a promising candidate for the management of Alzheimers and Parkinsons diseases.
