Pancancer analysis of CDCP1 reveals its carcinogenic mechanisms and prognostic value as a survival-related target

Although a growing body of evidence indicates that CDCP1 plays a crucial role in cancer initiation and progression, there remains a lack of systematic analysis regarding CDCP1 in cancer. Here, we conducted a comprehensive study of CDCP1 based on the Cancer Genome Atlas (TCGA) and the Clinical Proteomics Oncology Analysis Consortium (CATPAC) databases, aiming to explore its potential role and detailed mechanisms in 33 human tumors. The results showed that CDCP1 was highly expressed in many cancers, and the expression of CDCP1 was significantly correlated with the prognosis of cancer patients. DNA methylation levels of CDCP1 tended to decrease in most cancers and were inversely correlated with CDCP1 expression, which in addition significantly correlated with the level of infiltrating cells. In summary, the pancancer study described the relationship between CDCP1 expression and clinicopathological features in multiple cancer types, further showing its potential regulatory role in human cancer. This study is a systematic analysis of the function and role of CDCP1, which is a relatively comprehensive understanding of the oncogenic role of CDCP1 in different tumors.