Preoperative hyperbaric oxygen therapy for abdominal and gastrointestinal surgeries: a systematic review protocol
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Background : Major abdominal and gastrointestinal surgeries are frequently associated with significant postoperative complications, notably anastomotic leakage and mortality. Preoperative hyperbaric oxygen therapy (HBOT) has been proposed as an adjunctive intervention to optimize tissue oxygenation and improve surgical outcomes. Objective : To evaluate the clinical effects of preoperative HBOT on postoperative outcomes in adult patients undergoing abdominal or gastrointestinal surgery. Methods : This systematic review will include randomized controlled trials (RCTs) and observational studies (such as cohort and case-control studies). We will search MEDLINE (via PubMed), Embase, and LILACS for studies comparing preoperative HBOT to standard surgical care without HBOT. The primary outcomes will be postoperative mortality and the incidence of anastomotic leakage. Secondary outcomes include postoperative pain and length of hospital stay. Two independent reviewers will screen studies, extract data, and assess the risk of bias. If applicable, a meta-analysis will be performed. PROSPERO Registration: CRD420261339389
