Synthesis, Characterization and Biological Applications of Schiff Base Capped CdS Nanoparticles Prepared via an Ultrasonically Assisted Green Chemical Method

In the present investigation, a novel Schiff base ligand was synthesized by condensing benzaldehyde, o-hydroxyacetophenone, and 1,2-ethylenediamine using an ultrasonically assisted green chemical method. This ligand was subsequently employed to cap cadmium sulfide nanoparticles (CdS NPs), producing Schiff base capped CdS nanoparticles (L–CdS NPs). The synthesized Schiff base ligand and capped nanoparticles were characterized by elemental analysis, scanning electron microscopy (SEM), X-ray diffraction (XRD) and UV-Vis, IR, ¹³ C and ¹ H NMR and HRMS spectral techniques. XRD results confirmed the crystalline nature of CdS and indicated nanoscale crystallite size, with broadening of diffraction peaks signifying particle size reduction. The Schiff base capped CdS nanoparticles were further explored for their potential biological applications, including anticancer, and antibacterial activities. The study demonstrates that Schiff base capping not only stabilizes CdS nanoparticles but also enhances their biological activity, making them suitable candidates for future biomedical and nanotechnological applications.