Analysis of Risk Factors for Hypertension Comorbidity in Patients with Gout: A  Retrospective Study

Background Although the comorbidity of gout and hypertension is well-established, the independent predictors for hypertension in gout patients remain insufficiently investigated. This study was designed to identify such factors for hypertension in patients with primary gout. Methods In this retrospective study, 253 patients were recruited from the Rheumatology and Immunology outpatient clinic of Xi'an No.5 Hospital between March 2024 and July 2025. Data concerning demographics, biochemical indicators, and comorbidities, were collected. The analysis involved descriptive statistics, chi-square tests, and univariate and multivariate logistic regression to estimate odds ratios (ORs) and confidence intervals (CIs), followed by model diagnostics and sensitivity analyses. Results The findings demonstrated that age of onset (OR = 1.064, 95% CI: 1.035–1.094), Fasting blood glucose (FPG) (OR = 1.277, 95% CI: 1.010–1.614), 24-hour urinary uric acid excretion (UUE) (OR = 1.002, 95% CI: 1.000–1.003), creatinine clearance rate (Ccr) (OR = 1.017, 95% CI: 1.005–1.030), and serum creatinine (SCr) (OR = 1.035, 95% CI: 1.012–1.058) were significantly associated with hypertension in gout patients (all P  < 0.05). The model demonstrated good fit (the Hosmer-Lemeshow, P  = 0.458). Conclusions The study highlight aging, hyperglycemia, and abnormal renal function indicators as independent risk factors for hypertension in individuals with gout, suggesting that closer monitoring and early intervention may improve clinical outcomes.