Factors Associated with Psychological Well-Being among University Students in Administrative Programs in Colombia: An Analytical Cross-Sectional Study

Background University students frequently experience mental health challenges influenced by academic, personal, and social factors. Understanding the determinants of well-being and mental health in this population is essential for designing effective institutional interventions. This study aimed to identify factors associated with psychological well-being among university students in administrative programs in Colombia. Methods An analytical cross-sectional study was conducted among students enrolled in administrative programs at a private university in southwestern Colombia. A structured questionnaire was used to assess socio-demographic variables, lifestyle habits, and mental health indicators, including anxiety, depression, and subjective well-being. Data were analyzed using descriptive and bivariate statistics, followed by a multivariate logistic regression model to identify predictors of optimal well-being and mental health. Statistical significance was set at p  < 0.05. Results A total of 178 students participated (68.0% women; mean age = 21.3 ± 2.4 years). Higher levels of physical activity, perceived social support, and adequate sleep duration were positively associated with better mental health and well-being, while academic overload and financial stress were significant negative predictors. In the multivariate model, social support (OR = 2.43, 95% CI: 1.36–4.34), financial satisfaction (OR = 2.21, 95% CI: 1.23–3.97), and regular physical activity (OR = 1.78, 95% CI: 1.02–3.10) were significant predictors of adequate well-being, while perceived stress was negatively associated (OR = 0.56, 95% CI: 0.32–0.98). Conclusions These findings support the implementation of nursing-led mental health promotion strategies within university settings, emphasizing early detection, strengthening social support networks, and promoting healthy lifestyle behaviors to enhance student well-being. Institutional actions should prioritize preventive programs that address modifiable risk factors. These results support the integration of well-being promotion into higher education policies in Latin America.