AI-Driven analysis of Iron doped ZnO fluoronanomagnetsfor Molecular Drug Delivery and Hyperthermia forcancer therapy

This is a study of Fe-doped ZnO fluoronanomagnets (meaning luminescent and magnetic at the same time) integrated with artificial intelligence (AI)-assisted predictive modeling, magnetothermal-drug synergistic therapy concepts, tumor microenvironment responsiveness, and MRI-compatible image-guided hyperthermia frameworks. Using the structural, magnetic, and luminescent datasets, we propose AI-driven specific absorption rate (SAR) prediction models and thermal distribution simulations to optimize hyperthermia efficiency. The integration of ROS-mediated synergistic therapy and controlled drug delivery strategies enhances the translational potential of these multifunctional fluoronanomagnets. Targeted delivery of therapeutics possesses the potential to localize therapeutic agents to specific tissues as a mechanism to enhance drug delivery efficacy and mitigate side effects. Candidates that combine imaging and therapeutic modalities in a single macromolecular structure confer advantages in nanomedicine applications. ZnO:Fe synthesized by a simple co-precipitation chemical route and surface modified by the ligand folate. Functionalized fluoronanomagnets system combines the specificity of folate receptors on cancer cells with the excellent optical and magnetic properties of the nanoparticles so as to develop biocompatible molecular imaging agents, drug delivery systems and hyperthermia therapeutic agents. The vibrating sample magnetometer (VSM) studies showed clear hysteresis loops having coercivity 5.1 mT with corresponding magnetization of remanence 7.6 × 10 ^− 3 emu/g, indicating strong magnetic character of the samples. X-ray diffraction (XRD) and transmission electron microscopy (TEM) studies show that these nanoparticles are spherical with 6–9 nm size and hence are quite appropriate for in vivo applications as well. The immobilization of folic acid was confirmed by fourier transform infrared (FTIR) analysis. All these properties make these fluoronanomagnets one of the most feasible candidates for folate receptor mediated entitities for several biomedical applications.