Effect of KuanXiong Aerosol on Intraoperative Myocardial Ischemia Reperfusion Arrhythmia: A Propensity Score-Matched Case-Control Study

Objective Myocardial intraoperative reperfusion arrhythmia (RA) is very common during the procedure of percutaneous coronary intervention (PCI). This study aimed to investigate whether pre-administering of KuanXiong Aerosol (KXA) can reduce the risk of RA. Methods In this retrospective case - control study, patients diagnosed with acute myocardial infarction (AMI) who underwent PCI at Guangdong Provincial Hospital of Chinese Medicine from January 1, 2018 to December 31, 2023 were included. Clinical data were collected and propensity score match (PSM) was employed to balance baseline characteristics between KXA and control groups. Results A total of 2,168 cases of AMI patients were recruited, among whom 227 experienced reperfusion arrhythmia and 66 experienced major adverse cardiovascular events (MACE). Pre-administering of KXA was associated with a significant reduction in risk of RA ( P  < 0.001), consistent after PSM. The incidence of MACE also reduced following KXA administration ( P  = 0.034). Conclusion To our knowledge, this is the first study to demonstrate that KXA may have the potential to reduce the risk of intraoperative RA, and decrease incidence of MACE.