Improvements in scalp elasticity and hair properties following supplementation with low-molecular-weight porcine placental peptides (Placenderm®): A randomized, double-blind, placebo-controlled clinical trial

The aging of scalp and hair is a complex biological process characterized by reduced biomechanical elasticity and degradation of follicular support structures, resulting in altered hair physical properties and appearance. However, clinical evidence for nutritional interventions targeting these aging markers remains limited. This study investigated the effects of hydrolyzed low-molecular-weight porcine placental peptides (Placenderm®) on scalp elasticity and the biophysical and visible aging-related characteristics of hair. In this 24-week, randomized, double-blind, placebo-controlled, parallel-group trial, 100 adults were assigned to receive either Placenderm® (500 mg/day) or a placebo. Scalp elasticity (ballistometry), hair physical properties (diameter and tensile strength), hair shaft morphology and roughness (SEM and ImageJ analysis), and hair luster (SAMBA system and expert visual assessment) were evaluated at baseline and week 24. Subjective satisfaction and safety parameters were also monitored. After 24 weeks, the Placenderm® group demonstrated statistically significant improvements in scalp elasticity, hair diameter, and tensile strength compared with the placebo group. Scanning electron microscopy (SEM) analysis revealed a significant reduction in hair surface roughness (Ra) in the intervention group, suggesting attenuation of cuticle damage and structural degradation. In addition, hair luster scores and subjective satisfaction were significantly higher in the intervention group. No serious adverse events were reported. Oral supplementation with Placenderm® significantly improved scalp elasticity and hair physical and microstructural characteristics. These findings suggest that Placenderm® is a safe and effective nutritional intervention for mitigating age-related changes in the scalp and hair.