Impact of behavioral determinants on the control of type 2 diabetes mellitus: Translational nursing systematic review

Background Type 2 Diabetes Mellitus (T2DM) is a priority health challenge due to its prevalence and the clinical impact of poor glycemic control. Behavioral determinants play a central role in modulating metabolic outcomes within nursing practice. Aim: To determine the impact of behavioral determinants on glycemic control in adults with T2DM from a translational nursing perspective. Methods: Systematic review following PRISMA 2020 guidelines. Observational studies and randomized clinical trials evaluating self-care, self-efficacy, health literacy, and glycemic control (HbA1c) were included. Data were integrated using traceability and critical evidence matrices to normalize heterogeneous statistical metrics. Results: Nursing-led interventions and the strengthening of self-efficacy and self-care are associated with clinically significant improvements in HbA1c. Conversely, low health literacy was identified as a critical risk factor for metabolic poor control. Conclusion: Behavioral determinants are the main modulators of glycemic control in T2DM. Translational nursing emerges as a strategic axis for transforming scientific evidence into high-impact clinical interventions.