DCBLD1/CCNB1 Axis Confers Ferroptosis Resistance to Promote Breast Cancer Malignancy

DCBLD1 has emerged as an oncogene implicated in the progression of various cancers. Despite its recognized role in tumorigenesis, its precise mechanisms in breast cancer development remain largely undefined. Our comprehensive findings establish DCBLD1 as a crucial oncogenic driver and an independent prognostic indicator in breast cancer. Mechanistically, we demonstrate that DCBLD1 promotes malignant breast tumor progression by inhibiting ferroptosis through its direct regulation of CCNB1, ultimately leading to ACSL4 destabilization and degradation. This study unveils a novel DCBLD1-CCNB1-ACSL4 axis in ferroptosis regulation, providing critical insights into breast cancer pathogenesis and identifying potential therapeutic vulnerabilities