Efficacy of Benzydamine, Sodium Bicarbonate, and Ankaferd Hemostat Mouthwashes in Chemotherapy-Related Oral Mucositis

Aim Oral mucositis (OM) is a frequent and painful complication in patients undergoing chemotherapy for hematologic malignancies, with limited consensus on the most effective topical treatments. This study retrospectively compared the efficacy of three mouthwash agents; benzydamine hydrochloride, sodium bicarbonate (NaHCO3), and ankaferd hemostat in preventing and treating chemotherapy-induced OM. Materials and Method : Data from 82 patients were analyzed over a three-week period, assessing OM severity and laboratory parameters. Results Here we found that benzydamine hydrochloride and ankaferd hemostat were associated with lower rates of OM at the third week, whereas NaHCO3 use correlated with a higher incidence of OM. Additionally, higher platelet counts were linked to reduced OM risk. Discussion These findings suggest that benzydamine hydrochloride and ankaferd hemostat may offer better local mucosal protection than NaHCO3 in this patient population, highlighting the potential for improved supportive care strategies in chemotherapy-induced OM management.