AML with t(16;21)(p11.2;q22)/FUS::ERG rearrangement presenting with hemophagocytes and multinucleated cells: a case report and literature review

The FUS :: ERG fusion gene is rare in patients with acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS), with a predominant prevalence in individuals of Asian descent. The incidence of AML harboring the FUS :: ERG fusion gene is approximately 1%. To date, approximately 154 cases have been reported in the literature. SF3B1 mutation is also rare in AML and frequently coexist with other genetic abnormalities to drive leukemogenesis.In this article,A case of AML harboring t(16;21)(p11.2;q22)/ FUS :: ERG and CSF3R mutations was retrospectively analyzed, with frequent identification of hemophagocytes and multinucleated cells in the bone marrow, and the relevant literature was reviewed.