Logistic regression analysis of influencing factors of bronchial lesions in children with Mycoplasma pneumonia

Objective: To investigate the incidence, clinical features, laboratory indices and independent risk factors of bronchial organic lesions in children with Mycoplasma pneumoniae pneumonia (MPP) after standard treatment. Methods: According to bronchoscopy results,383 cases of MPP were divided into organic lesion group and non-organic lesion group. The clinical characteristics and laboratory indexes of the two groups were compared. The independent risk factors of organic lesions were analyzed by Logistic regression. Results: The incidence of bronchial organic lesions in children with MPP was 17.5%. Compared with the non-organic lesion group, the proportion of moist rales in the organic lesion group was significantly lower (59.70% vs 77.53%, P<0.05), and the duration of normal body temperature was significantly prolonged (5.85±2.52 days vs 5.06±2.60 days, P<0.05). In laboratory indicators, the levels of D-dimer (DD) and fibrinogen degradation product (FDP) were significantly elevated, while the levels of albumin and creatine kinase (CK) were significantly reduced in the organic lesion group (all P<0.05). At follow-up, the white blood cell count (WBC) in the organic lesion group was significantly higher than that in the non-organic lesion group (P<0.05). Logistic regression analysis showed that negative moist rales (OR=0.302,95% CI: 0.159-0.575) and neutrophil count (NC) at follow-up (OR=1.053,95% CI: 1.005-1.104) were independent risk factors for bronchial organic lesions in children with MPP (all P<0.05). Conclusion: The incidence of bronchial organic lesions in children with MPP is about 17.5%. The negative sputum crackles and elevated NC in follow-up visits are independent risk factors. Clinicians should pay attention to such children and perform bronchoscopy as early as possible to improve prognosis.