Unusual parotid gland localization of Abrikossoff tumor

This report details a rare case of a benign granular cell tumor (Abrikossoff’s tumor) originating in the parotid gland of a 35-year-old woman. The patient presented with a one-year history of a slowly enlarging, painless left pre-tragal mass. Imaging revealed a heterogeneous, poorly defined lesion with calcifications. The patient underwent a total parotidectomy with facial nerve preservation. Histopathological examination revealed tumor cells with abundant granular cytoplasm and absent cytonuclear atypia. The diagnosis was confirmed by immunohistochemistry, which showed strong positivity for PS100, SOX10, and CD68, and negativity for DOG1 and mammaglobin. GCTs are uncommon, typically benign neoplasms often linked to a Schwann cell origin, with parotid localization being exceptionally rare. Complete surgical excision is the standard treatment to prevent recurrence. This case underscores the importance of immunohistochemistry in diagnosing this rare entity and confirms that complete resection provides excellent outcomes.