Liver SWE elastography performed in the newborn period is a reliable method for predicting hepatic failure in infancy.

Objectives: Elastography is a modern, non-invasive technique that quantifies tissue stiffness and is valuable in pediatric hepatology. Study design: This observational study included 137 children. Shear wave elastography (SWE) was used to establish normal ranges, assess its role in early fibrosis detection, and monitor treatment response. Results: Retrospective data analysis confirmed the examination’s repeatability. Elastography values were independent of age and weight but correlated with circulatory and hepatic insufficiency. Median SWE EQI values for the right lobe were 10.89 kPa (term), 10.7 kPa (32–36 GW), and 9.50 kPa (<32 GW); for the left lobe, 9.68 kPa, 9.7 kPa, and 9.41 kPa, respectively. The left lobe elasticity cut-off predicting neonatal chronic liver failure was 13.78 kPa. Conclusions: Liver elastography is a reliable, repeatable, and non-invasive tool that may enable early prediction of liver cirrhosis risk and support monitoring of hepatic function in newborns.