Structure–Activity Relationship and ADME-Guided Optimization of 4H-Chromene-3-Carbonitrile Derivatives as Promising Antimicrobial Agents

The wide range of biological activities and advantageous pharmacological characteristics of 4H-chromene derivatives have drawn a lot of attention. In this work, a variety of 4 H -chromene-3-carbonitrile derivatives were synthesized under ideal conditions using an environmentally friendly and effective multicomponent process. High yields, quicker reaction times, and less environmental effect were provided by the synthetic protocol. Several derivatives with significant antibacterial and antifungal properties were found when the synthetic compounds' antimicrobial activity was assessed. ADME prediction experiments also showed appropriate pharmacokinetic behavior, excellent drug-likeness, and oral bioavailability. All things considered, the findings point to these 4H-chromene derivatives as viable options for more medicinal chemistry research.