Airway Coach Project: Development of a Machine Learning–Based Model Using Clinical and Ultrasound Parameters to Support Videolaryngoscopy Strategy

Background Videolaryngoscopy (VL) is recommended as a first-line technique for tracheal intubation; however, existing airway assessment tools—largely derived from direct laryngoscopy—provide limited guidance for videolaryngoscopy-specific decisions such as blade selection or anticipated adjunct use. Point-of-care airway ultrasound offers additional anatomical information that may complement conventional clinical assessment. Multimodal approaches integrating clinical and ultrasound-derived variables may improve pre-procedural videolaryngoscopy planning. Methods In this single-centre prospective observational study, 250 adults (ASA physical status I–III) undergoing elective surgery were assessed preoperatively using clinical variables and point-of-care airway ultrasound. Videolaryngoscopic intubation was initiated with a Macintosh-type blade and prospectively classified according to procedural performance: Grade 0 (Macintosh blade without adjuncts), Grade 1 (Macintosh blade requiring adjuncts), and Grade 2 (need to switch to a hyperangulated device). Machine-learning models were developed using stratified cross-validation on a training dataset and evaluated on an independent test set. Results In the independent test set, a gradient boosting model demonstrated good discriminative performance for videolaryngoscopy strategy classification (AUC 0.95; accuracy 92%). Performance varied across outcome categories, with lower precision in less frequent classes (F1-score 0.67 for Grade 1 and 0.75 for Grade 2). Classification was driven by a combination of tongue-related ultrasound parameters, anterior neck soft-tissue distances, body-mass index, and age. Conclusions In this single-centre observational study, a machine learning–based model integrating clinical and airway ultrasound variables was developed to support videolaryngoscopy strategy planning. This multimodal, data-driven approach demonstrates feasibility and warrants further evaluation in independent populations before clinical implementation. Trial registration This study was registered at Clinical Trial.gov NCT 06925009