Metabolic Risk Stratification for Urinary Tract Infection:Clinical Implications of Combined Hyperuricemia and Hyperglycemia in a Multicenter Study

Objective: To explore the effects of hyperuricemia and hyperglycemia on microbial bacteria in culture-positive Urinary tract infections (CP-UTIs). Methods: A multicenter retrospective analysis method was used to collect 243 urine samples from patients with Urinary tract infections in 6 hospitals of different levels in different regions of mainland China from 2023 to 2024 for bacterial flora analysis. They were divided into the culture-positive Urinary tract infections（CP-UTIs） group and the culture-negative Urinary tract infections（CN-UTIs）group. The data of serum glucose, serum uric acid, urine pH, urine glucose, and midstream urine culture results were statistically analyzed using Prism and SPSS software. Results: There were significant differences in Age between male and female patients ( P = 0.0049<0.05 ) and in serum uric acid levels ( P <0.0001). There were also significant differences in the microbial flora between patients with normal serum uric acid levels and those with hyperuricemia, as well as between patients with Urinary tract infections ( P <0.0001). However, there were no significant differences in serum glucose, urine glucose, and urine pH levels between patients with culture-positive Urinary tract infections and those with culture-negative Urinary tract infections (P > 0.05). Conclusion: Contrary to previous research findings, our investigation revealed that not only serum glucose but also serum uric acid exerts a significant influence on the microbial flora associated with urinary tract infections. This discovery holds considerable implications for the prevention and treatment of urinary tract infections in adults.