Anti-thrombospondin-1 autoantibody indicated increased disease activity and xerophthalmia incidence in Primary Sjögren's syndrome

Objective. The relationship between anti- thrombospondin-1 antibody (anti-TSP-1) and the clinical manifestations of Primary Sjögren's syndrome（pSS) has not been fully clarified.We analyzed the clinical factors relevance of anti-TSP-1 in pSS. Methods. Serum ATSA was detected by ELISA in 70 pSS patients and 21 healthy controls enrolled. Results. Anti-TSP-1 antibody is significantly higher in pSS patients (10.63± 4.92 vs. 7.64 ± 4.70, t =2.403, P =0.019). Positivity of anti-TSP-1 antibody in pSS and HCs were respectively 51.4% (36/70) and 28.6%(6/21). The increase of anti-TSP-1 antibody was also significantly correlated with the increase of IgG ( r = 0.263, P =0.029) and RF ( r =0.421, P ＜0.001), and the decrease of C4 ( r =-0.253, P =0.035)in pSS patients. The increase of serum anti-TSP-1 antibody was associated with the increase of ESSDAI in pSS patients ( r =0.277, P =0.02). Further statistical analysis showed that γG% values of anti-TSP-1 positive group were significantly higher than those of anti-TSP-1 negative group ( t =2.554, P =0.014). γG% values of anti-TSP-1 positive group were significantly higher than those of anti-TSP-1 negative group ( t =2.554, P =0.014).What’s more,the incidence of xerophthalmia significantly increased in the anti-TSP-1 positive group ( c ² =4.939, P =0.026). Conclusion. Anti-TSP-1antibody levels were associated with increased SS disease activity,and it may be an effective tool in screening and predicting prognosis in pSS patients