Clinical and Functional Outcomes After Laparoscopic IPOM Repair: A Comparison Between Hybrid Biosynthetic and Conventional Meshes

Background Laparoscopic IPOM repair is widely used for ventral hernia treatment. Hybrid biosynthetic meshes have been developed to improve tissue integration and functional recovery; however, comparative clinical evidence remains limited. Methods This was a single-center retrospective study conducted at a tertiary care institution between 2020 and 2025 including 95 consecutive patients undergoing laparoscopic IPOM repair. Forty-two patients received a hybrid biosynthetic mesh (SINECOR®) and 53 a conventional synthetic mesh. Demographic, clinical and surgical variables were analyzed, including defect size, mesh surface, operative time, complications, length of stay, functional and occupational recovery time, and quality of life (EuraHS-QoL). Hernia defects were classified as small (≤20 cm²), medium (21–100 cm²) and large (>100 cm²). Mesh size was categorized as small (≤150 cm²), medium (151–400 cm²) and large (>400 cm²). Delayed functional recovery was defined as occupational recovery >30 days. Multivariable logistic regression was performed to identify independent predictors of delayed recovery. Results Hybrid mesh was associated with significantly shorter operative time, reduced length of stay, faster functional and occupational recovery, and higher quality-of-life scores. Overall complication rates were comparable between groups. Recurrence was less frequent in the hybrid group, although follow-up was shorter. On multivariable analysis, hybrid biosynthetic mesh remained the only independent predictor of faster functional recovery. Conclusions Hybrid biosynthetic mesh was associated with improved functional recovery and quality of life for small-to-medium defects, with a safety profile comparable to conventional meshes. Larger prospective studies are warranted.