Association of triglyceride-glucose index and its combined obesity indicators and kidney stones in the non-diabetic population of southwestern China

Background Although the triglyceride-glucose (TyG) index has been previously linked to kidney stones (KSs) formation, evidence remains limited from Southwest China. We aim to investigate the association between TyG and its combined obesity indicators and KSs prevalence among adults without diabetes in this understudied region. Methods The Data was obtained from the database of the Health Management Center of Sichuan Provincial People's Hospital during March 2015 to December 2021. 87,399 non-diabetic individuls who were not pregnant, over 18 years old, and able to provide complete data about TyG index and its combined obesity indicators, as well as KSs results, were included in the analysis. Multivariable regression analysis and subgroup analysis were preformed to estimate the independent relationship between TyG and its combined indicators and KSs. Results 2,575 (2.95%) participants were diagnosed with KSs, andthe prevalence of KSs was higher in males, older individuals, smokers, drinkers, and those with hypertension or dyslipidemia. TyG and its combined indicators (TyG-WC, TyG-WHR, TyG-BMI, TyG-NC, TyG-WHtR) showed significant positive associations with KSs risk (all P for trend < 0.001).ROC curves confirmed combined indicators had higher diagnostic accuracy than TyG alone.Subgroup analysis showed that TyG-BMI, TyG-NC, TyG-WHtR in male subgroup, as well as TyG-WHtR in subgroup under 50 years old and non-hypertensive subgroup were positively correlated with the prevalence of KSs (P for interaction < 0.05). Conclusions Elevated TyG and its combined obesity indicators are positively linked to KSs risk, and the TyGcombined indicators have a stronger association with KSs risk than the TyG alone, suggests that improving insulin resistance including weight management may reduce the KSsformation.