Bibliometric Mapping of Transcatheter Edge-to-Edge Repair in Mitral Regurgitation, 2006-2025

Background: Mitral regurgitation (MR) is a common valvular heart disease closely associated with heart failure, significantly impacting patients' quality of life and prognosis. Transcatheter edge-to-edge repair (TEER) has garnered significant attention in the field of mitral regurgitation management in recent years as a minimally invasive therapeutic approach. This bibliometric analysis aims to visualize the evolutionary trends in this research domain, identify key contributing authors and collaborative networks, outline emerging research topics, and reveal the implications for clinical guideline updates and global research cooperation—providing actionable insights for technical optimization and clinical translation. Methods: A systematic literature search was conducted for publications related to Mitral Transcatheter Edge-to-Edge Repair between 2006 and 2025 using the Web of Science Core Collection database. The publication trends, countries/regions, keywords analysis, institutions, authors, references and co-citation journals were analyzed and evaluated using tools including CiteSpace, VOSviewer and R-bibliometrix. Results: The analysis included 1,345 publications authored by 5,856 researchers from 1016 institutions across 66 countries and regions. The United States and Germany demonstrated leading research output in this field, contributing 376 and 364 publications, respectively. Vita-Salute San Raffaele University and IRCCS Ospedale San Raffaele emerged as the most productive institutions. Dr. Kar S was identified as the most influential author with an H-index of 35, followed by Dr. Buldus S and Dr. Maisano F, each with an H-index of 28. Key journals disseminating research in this domain include Catheterization and Cardiovascular Interventions and JACC: Cardiovascular Interventions. Keyword evolution analysis revealed a notable transition in research focus: from early traditional surgical techniques (e.g., "edge-to-edge technique," "annuloplasty," "double orifice technique") to mid-stage minimally invasive and systemic clinical investigations (e.g., "percutaneous mitral valve repair," "system"), and currently advancing toward refined interventional technologies and complex complication management (e.g., "mitral transcatheter edge-to-edge repair," "cardiogenic shock"). Conclusions: This study provides researchers in the field with a panoramic academic perspective, facilitates the rapid identification of core research teams, key technical nodes, and cutting-edge exploration directions, and offers clear references for cross-institutional and cross-border academic cooperation.