Correlation Between the Severity of Primary Mitral Regurgitation and Left Ventricular Ejection Fraction in Patients With Mitral Valve Prolapse Assessed by Cardiac Magnetic Resonance: A Cross-Sectional Study

Background The increasing systolic dysfunction and persistent left ventricular volume overload caused by primary mitral regurgitation (MR) are symptoms of this prevalent valvular heart disease. LVEF decreases and ventricular remodeling occurs in individuals with MVP as the severity of regurgitation increases. Examining LVEF as measured by CMR in relation to the degree of primary mitral regurgitation was the major objective of this research. Methods The research team at Dr. Hasan Sadikin General Hospital used a cross-sectional design and ran the study from October 2021 to October 2025. The data was collected from the medical records of individuals who were 18 years old or older and had a diagnosis of MVP and had a CMR scan. Regurgitant volume and regurgitant fraction were used to measure the severity of mitral regurgitation, while left ventricular function was determined using LVEF. In order to assess the relationship between the variables, we used Spearman rank correlation analysis. Results The results showed that there was a strong negative relationship (p < 0.05) between the severity of primary mitral regurgitation and LVEF, suggesting that lower LVEF was linked to more severe regurgitation. Conclusions In individuals with mitral valve prolapse, the severity of primary mitral regurgitation is significantly correlated with left ventricular ejection fraction as measured by CMR.