Gas Combination Cryotherapy as an Adjuvant in the Management of Benign Odontogenic Jaw Lesions: A Prospective Clinical Study

Purpose Benign odontogenic lesions, including odontogenic keratocyst, ameloblastoma, and adenomatoid odontogenic tumor, are locally aggressive jaw lesions with a high risk of recurrence. Their management ranges from conservative procedures to radical resections, but countering recurrence still remains a challenge. Various adjuvants such as chemical cauterizing agents like Carnoy’s solution and thermal methods including cryotherapy have been utilized to reduce recurrence rate. Hence, present study was aimed to evaluate the management outcome for benign odontogenic lesions having high recurrence rate following usage of gas combination cryotherapy as an adjunct. Methods Thirty-three patients aged 20–50 years having benign odontogenic lesions with high recurrence rate were included. Patients with lesion recurrence following previous surgery were excluded. Lesion dimensions, bone density and volume were measured pre- and postoperatively using cone-beam computed tomography. Incidence of neurosensory disturbances, pathological fracture and recurrence too were noted. Wilcoxon signed-rank test was used to evaluate lesion size and volume, paired t-test for bone density, and Cochran’s Q-test for neurosensory outcomes, with significance set at P  ≤ 0.05. Results Results showed a significant 91.83% overall reduction in lesion volume, with maxillary and mandibular lesions reducing by 83.15% and 94.05%, respectively ( P  < 0.001). Bone density improved significantly from 189.80 to 480.50 Hounsfield Units, indicating considerable bone regeneration ( P  < 0.001). The treatment was well tolerated with minimal complications and no recurrence observed during entire follow-up. Conclusion These findings suggest GCC is a safe and effective adjunctive treatment to enhance bone healing and reduce recurrence rates in aggressive benign odontogenic lesions of the jaw.