Immune Dysregulation in Recurrent Dermatological Viral Afflictions: A Focus on Th17/Treg Axis Imbalance

This paper investigates the immunological underpinnings of a prevalent recurrent dermatological condition, characterized by frequent cutaneous outbreaks. While the precise pathogenesis remains elusive, this clinical experimental research aims to elucidate the role of specific immune cell subsets and associated cytokines. Peripheral blood samples were analyzed to assess the balance between regulatory T cells (Treg) and T helper 17 (Th17) cells, pivotal for maintaining immune homeostasis. Our findings reveal a significant alteration in the Th17/Treg balance in affected individuals compared to healthy controls, alongside notable changes in key inflammatory and regulatory cytokine profiles. This paper posits that such immune dysregulation is an important determinant in the occurrence, development, and resolution of this common skin disorder, offering critical insights into its underlying immunological mechanisms.