Analysis of clinical characteristics and related factors of primary pulmonary adenocarcinoma with Spread through air space

Objective To research the clinical traits and associated elements of primary lung adenocarcinoma with air space dissemination. Methods To conduct this study, we looked back at the medical records of 200 patients who had primary lung adenocarcinoma and had surgery at our institution between January 2015 and October 2017. Based on whether or not there was concurrent dispersion via air space, they were separated into the non STAS group (153 instances) and the STAS group (47 cases) (STAS). Univariate and multivariate unconditional logistic regression analyses were performed on the obtained patient data to determine the clinical features and relevant variables of STAS in relation to primary lung cancer; Rates of survival were compared between the two groups; STAS was correlated with survival time for those with primary lung adenocarcinoma using the Pearson correlation coefficient. Results Compared with the non STAS group, the proportion of tumor diameter > 3cm, part of solid nodules, solid nodules, clinical stage Ⅲ~Ⅳ, perineural invasion, lymphatic vessel invasion, vascular invasion, pleural invasion, lobulation sign, bronchial sign and vascular cluster sign in the STAS group increased significantly ( P  < 0.05); Independent risk variables for STAS-related primary lung adenocarcinoma were tumour size, tumour nodule type, clinical stage, perineural invasion, lymphatic vessel invasion, vascular invasion, and pleural invasion (P < 0.05); Survival rates at 3, 4, and 5 years were substantially lower (P < 0.05) for those with STAS compared to those without STAS (82.98 percent, 70.21 percent, and 68.09 percent, respectively). There was a significant inverse correlation between STAS and survival time in patients with primary lung adenocarcinoma (r=-0.423, P = 0.007). Conclusion STAS associated with primary pulmonary adenocarcinoma mostly occurs in patients with larger tumor diameter, solid nodules, higher clinical stage, perineural infiltration, lymphatic vessel infiltration, vascular invasion, pleural invasion, lobulation sign, bronchial sign, and vascular cluster sign. Many factors contribute to it, and it is directly connected to patients' survival rates, therefore it serves as a valuable benchmark for clinical research and patient care.