In-silico docking of Ibezapolstat (ACX-362E) on S.aureus and M.genitalium DNA polymerases

Staphylococcus aureus and Mycoplasmoides genitalium cause a wide range of infectious diseases via potent and diverse molecular mechanisms and are also highly resistant to antibiotics. In this in silico study, the docking of Ibezapolstat on the polC DNA polymerase of Mycoplasmoides genitalium and Staphylococcus aureus was performed with positive controls of docking known inhibitors of Clostridium difficile polC and Staphylococcus aureus polC. The average AC score (a parameter that assesses binding affinity) for M.genitalium was -92.6 and for S.aureus -95.8, which was very close to the positive controls of -92.96 and -99.94. These findings show great promise for the potential of treating S.aureus and M.genitalium infections with the novel antibiotic Ibezapolstat, and in vitro and in vivo studies on this are warranted.