Feasibility of Cone Beam Breast CT–Guided Wire Localization for Non-Palpable Breast Lesions

Objective: To evaluate the clinical value of cone-beam breast computed tomography (CBBCT) in wire localization for non-palpable breast lesions. Methods: A total of 39 patients with 45 non-palpable breast lesions underwent wire localization guided by CBBCT. Operation time, intraoperative complications, radiation dose, and postoperative pathological outcomes were recorded to assess the success rate and safety of CBBCT-guided wire localization. Results: CBBCT-guided wire localization was successfully performed in all 39 patients (40 breasts, 45 lesions), achieving a success rate of 100%. No intraoperative complications occurred. Postoperative pathology confirmed complete excision of all localized lesions. The average time spent with non-contrast CBBCT guided wire localization is 27.54±5.83 minutes. When contrast-enhancement CBBCT is used for wire localization, the average time spent is 30.73±5.62 minutes. The difference in operation time is statistically significant with p<0.05. Conclusion: CBBCT-guided wire localization offers a precise and reliable method for preoperative localization of non-palpable breast lesions. It effectively provides accurate guidance for breast lumpectomy without the limitations of conventional image-guided techniques.