Organic Psychosis in A Male Adolescent With Cerebral Palsy: A Case Report And Review of The Literature

Background: Cerebral palsy (CP) is a neurodevelopmental condition associated with motor impairment and cognitive challenges. Although psychiatric comorbidities are common, psychotic symptoms are rarely documented. Early recognition of organic psychosis in CP is essential for effective intervention. Case Presentation: We report a 15-year-old male adolescent with spastic quadriplegic CP who presented with acute psychotic symptoms, including persecutory delusions, disorganized behavior, referential ideation, and presumed auditory hallucinations. Neuroimaging revealed chronic periventricular leukomalacia. Symptoms emerged following academic stress and social isolation. Treatment with risperidone and olanzapine led to significant clinical improvement. No major extrapyramidal side effects occurred aside from transient akathisia. Discussion: Psychosis in CP may arise from structural brain abnormalities, psychosocial stressors, and cognitive vulnerabilities. Differentiating organic psychosis from primary psychotic disorders is essential for treatment planning. Limited literature exists regarding psychopharmacology in CP, emphasizing the need for further research. Conclusion: This case highlights the complexity of managing psychosis in CP and underscores the importance of early identification, multidisciplinary care, and individualized treatment strategies.