Improvement of Pattern Electroretinogram Parameters Following Glaucoma Surgery

Purpose To assess the dynamics of Pattern Electroretinogram (PERG) parameters following glaucoma surgery in individuals with glaucomatous optic neuropathy. Methods The is a single center retrospective study. Preoperative PERG were conducted on moderate and advanced glaucoma patients scheduled for glaucoma surgery. Subsequently, the patients underwent an additional PERG a few months after the procedure. Comparative analysis focused on the PERG parameters (Mag, MagD and MagD/Mag ratio) before and after the glaucoma surgery in eyes achieving successful intraocular pressure (IOP) reduction post-operatively. Results The study enrolled 27 eyes from 24 consecutive patients who underwent successful glaucoma surgery between January 2021 and December 2023, each with both pre and post-operative PERG assessments. Postoperatively, there was a significant improvement of all the PERG parameters (0.94 ± 0.3 to 1.29 ± 0.3 µV, 0.54 ± 0.3 to 0.81 ± 0.41 µV, 0.54 ± 0.19 to 0.67 ± 0.26 for Mag, MagD and MagD/Mag ratio respectively, p < 0.01). Three patients who had no IOP reduction postoperatively showed no improvement of all PERG parameters following the surgery. Conclusions Glaucoma surgery, leading to effective IOP reduction, may demonstrate a positive impact on the functional activity of the retinal ganglion cells, as evidenced by the enhancement in PERG parameters post-operatively.