Computed Tomography Features Show Excellent Inter-radiologist Reproducibility and Malignancy Grading for Ovarian Teratomas.

Objectives: To evaluate the reproducibilities of computed tomography (CT) features among patients with ovarian teratoma tumors. Methods: This retrospective study included 32 patients with confirmed mature cystic teratoma and embryonic teratoma, recruited between January 2008 and June 2021. The study protocol has been pre-registered at (https://osf.io/n6fw5/) on the Open Science Framework (OSF) platform. Patients under the age of 20 who received transabdominal ultrasonography and/or abdominal and pelvic CT scans prior to surgery and underwent surgery at our institution were included. A gynecologic oncologist and a board-certified radiologist, both having extensive experience, interpreted CT scans for the following specifications: a) maximum diameter of calcifications (cm), b) number of calcifications, c) maximum diameter of fats (cm), and d) number of fats. Results: The intraclass correlation coefficient (ICC) for maximum diameter of calcifications, number of calcifications, maximum fat diameter, and number of fat were 0.994 (CI = 0.980 to 0.998), 0.991 (CI = 0.975 to 0.997), 0.988 (CI = 0.967 to 0.996), and 0.977 (CI = 0.936 to 0.993), respectively. Also, the maturity of the tumor was more strongly correlated to the number of fat, the maximum diameter of calcifications, and the number of calcifications, with Pearson correlation coefficients of 0.846, 0.806, and 0.682, respectively. Conclusion: Our findings demonstrated excellent inter-reader agreement for all four CT measurements. This indicates a high consistency in CT-based evaluations of ovarian teratomas, which could enhance diagnostic accuracy and inform clinical decision-making.