The Youngest Male Breast Clear Cell Hidradenoma Case: A Literature Review

Background: Clear cell hidradenoma (CCH) of the breast is an exceedingly rare adnexal tumor, with a strong female predominance and typical presentation in middle-aged to elderly patients. While breast masses in children are uncommon and predominantly benign, CCH in the pediatric population, particularly in males, represents a scarcely documented phenomenon. Case Presentation: We report the case of a 6-year-old boy who presented with a several-month history of a non-healing, oozing wound on the left nipple-areolar complex. Examination revealed a 1-cm, subcutaneous, ulcerated, and hyperemic nodule. Ultrasonographic evaluation described a lobulated, cystic nodule measuring 23x15 mm. The mass was surgically excised via an O-T plasty technique, preserving the nipple. Histopathology confirmed clear cell hidradenoma. Due to an involved surgical margin identified on pathology, a complete re-excision was performed two months later. The patient recovered uneventfully and has been disease-free for 12 months of follow-up. Conclusion: To our knowledge, this represents the youngest documented male case of breast CCH in the global literature, surpassing the previous youngest male case by 12 years. This report expands the demographic spectrum of this rare entity. It underscores the importance of including CCH in the differential diagnosis of pediatric breast lesions. Complete surgical excision with clear margins remains the cornerstone of management to prevent recurrence, even in young children.