Inferring absolute cell proliferation and death rates from non-longitudinal single-cell transcriptomics
Discuss this preprint
Start a discussion What are Sciety discussions?Listed in
This article is not in any list yet, why not save it to one of your lists.Abstract
Cell proliferation and death rates are central to tissue biology but measuring them in vivo remains a persistent challenge. Here we present tissue dynamics inference (TIDYI), which quantifies absolute cell proliferation and death rates from non-longitudinal single-cell RNAseq snapshots. TIDYI expands the capability of single-cell RNAseq to extracting the cell dynamics of healthy and pathological tissues in vivo.
