Post-Traumatic Infected Thigh Ulcer Successfully Managed with Serial Debridement and Topical GrowthFactor Therapy: A Case Report

Burn and traumatic wound healing rely heavily on the coordinated activity of multiple growth factors that regulate angiogenesis, fibroblast proliferation, epithelial regeneration, and extracellular-matrix remodeling. In this report, we describe the successful treatment of a post-traumatic infected thigh ulcer managed with serial surgical debridement followed by combined topical and intralesional growth-factor therapy (BIOSKINCELL®). After initial debridement and infection control, the patient received a protocol of growth-factor application over several weeks, resulting in rapid granulation, progressive epithelialization, and complete wound closure without the need for grafting or flap coverage. The favorable outcome observed mirrors evidence from experimental and clinical studies showing that exogenous administration of factors such as basic fibroblast growth factor (bFGF) and vascular endothelial growth factor (VEGF) can enhance angiogenesis and epithelial repair. This case reinforces the therapeutic value of biologically active wound therapies when applied to a well-prepared wound bed and highlights their potential to accelerate healing, reduce complications, and improve reconstructive outcomes in complex soft-tissue injuries.