Neuro-Immune-Endocrine Integration Failure (NIEIF)

Some patients present with overlapping but unexplained symptoms pelvic pain, fatigue, urticaria, palpitations, gastrointestinal distress, neuropathic pain, and mood dysregulation. These symptoms, traditionally diagnosed under separate labels (endometriosis, MCAS, IBS, dysautonomia, chronic fatigue),We share a unifying pathophysiological signature disruption of neuro-immune-endocrine coordination.We define this as Neuro-Immune-Endocrine Integration Failure (NIEIF) , clinically observed as the Purusharth–Neha Multisystem Stress-Responsive Dysregulation Syndrome (PN-MSRDS) . NIEIF represents a systems-level breakdown in communication between mast cells, cytokine networks, neurogenic circuits, and hormonal regulators. This article expands the mechanistic model, clinical spectrum, diagnostic algorithms, and therapeutic rationale for this newly characterized condition.