DNA Origami Windmill Tetramer Model

Although the classic DNA double helix model proposed by Watson and Crick explains the static storage mechanism of genetic information, it fails to reasonably account for the physical driving force behind high-speed and high-fidelity DNA replication. Furthermore, the core features of Rosalind Franklin's X-ray diffraction Pattern 51—"alternating black and white stripes with a slight tilt"—have not been fully interpreted within the static framework. Based on the standard B-type DNA double helix as the basic unit, this hypothesis proposes an original DNA Origami Windmill Tetramer Model by drawing on MacKinnon's research on the tetrameric structure of potassium ion channels and the mechanical principles of the potassium ion channel origami windmill model. Four DNA double helices assemble into an inverted conical tetrameric functional unit at a non-90° oblique angle corresponding to the diffraction characteristics of Franklin's Pattern 51, forming an inverted conical ion channel at the center. Its dynamic drive relies on the electrostatic repulsion of intracellular cations such as K⁺ and Na⁺, without the need for ATP hydrolysis for energy supply. The core of the model follows the logic of whole-chain non-denaturing replication, realizing genetic transmission through pairing and recombination between double-helix units, thereby avoiding the mismatch risk caused by single-strand exposure⁷. This reasonably explains the replication phenomenon in minimalist systems such as archaea and φ29 bacteriophages that do not require helicases, and clarifies that the classic enzyme system is only an auxiliary regulatory factor in the complex chromatin environment. Combining the core laws of molecular theory and 2ⁿ exponential logic, this study corrects the definition deviation between traditional DNA structural units and genetic functional units, confirming that the tetramer composed of 4 double helices is the optimal functional unit for complete DNA inheritance. Meanwhile, it is the first to reveal the direct correlation between the diffraction characteristics of Franklin's Pattern 51 and the folded stacking shape of the model's blades, breaking through the limitations of static cognition. This hypothesis provides a new and testable theoretical framework for dynamic DNA replication, whose predictions can be verified through five layers of decisive experiments. It is highly compatible with the classic double helix model and offers a testable theoretical perspective and experimental basis for research in related fields.