DNA Dynamic Regulation Theory Based on Potassium Channel “Origami Windmill” Model

This article proposes an original DNA origami windmill model, based on the potassium channel “origami windmill” model, to systematically reveal a new molecular mechanism of DNA dynamic regulation. The core structural feature of this model is the inverted conical core pore (with an outer diameter much larger than the inner diameter), which is maintained in stability and dynamic activity by tetramer units through the mechanism of “ion repulsion driven rotation”, forming a deep mechanical resonance with the potassium channel “origami windmill” model. The model structure can be intuitively understood through concrete examples such as “carrots”: a carrot with a central axis connected is regarded as an inverted cone-shaped nuclear pore structure (with a small upper diameter and a large base diameter), vertically divided into four lobes corresponding to the spatial arrangement of DNA tetramers. The cross-sectional layering pattern is highly consistent with the structural characteristics of each single stranded double helix in the tetramer, and the contour of the four lobes in the top view is consistent with the core morphology of Franklin's original X-ray diffraction pattern. The key innovation of this article is to confirm the direct correlation between the X-ray diffraction characteristics of Franklin Figure 51, which are black and white with slight slanting, and the shape of folded windmill blade stacks. Origami windmill - The periodic spatial structure formed by the folding and stacking of blades produces black and white alternating diffraction fringes under X-ray irradiation. The slight inclination of the blades causes the diffraction fringes to exhibit a “slanting” characteristic, providing key experimental phenomenon support for the rationality of the model. This theory breaks through the static cognition of traditional DNA structure research, with “dynamic regulation” as the core innovation point, providing a new research perspective and theoretical basis for analyzing the molecular mechanisms of life processes such as DNA replication and transcription.