Is There An Association Between 25(OH)D Serum Levels and Vitamin D Status with The Severity of Androgenetic Alopecia Severity in Men?

Background: Androgenetic alopecia (AGA) is characterized by progressive miniaturization due to androgen sensitivity. AGA is a multifactorial condition, and its severity is likely influenced by many factors. Deficiency in vitamin D can disrupt epidermal differentiation and hair follicle growth. To date, research thatprovides baseline data on vitamin D status, serum 25(OH)D levels in men with AGA and the link between vitamin D and severity of male AGA is limited, especially in Indonesia. This study examines the relationship between vitamin D status, serum 25(OH)D levels, and AGA severity in men. Methods: This cross-sectional study included 74 male subjects. AGA diagnosis was classified into mild-moderate-severe using the Hamilton-Norwood classification. Serum 25(OH)D levels were analyzed by chemiluminescent microparticle immunoassay (CMIA). Results: Among the participants, 45 individuals (60.8%) exhibited moderate to severe AGA. The average serum 25(OH)D level was 18.9 ± 5.89 ng/mL. A total of 35.1% were classified as non-deficient (including 3 patients with normal vitamin D levels), while 64.9% were categorized as deficient. Those with mild AGA had a mean level of 21.8 ± 6.39 ng/mL, while those with moderate to severe AGA had a mean level of 17.1 ± 4.79 ng/mL. There was a significant association between serum 25(OH)D levels and AGA severity (p=0.01) and between hair diameter and AGA severity (p=0.036). Conclusion: There is a significant association between vitamin D status and serum 25(OH)D levels with AGA severity in men.