Design & Analysis of a Highly Sensitive Biosensor for Detecting Breast Malignancy using a Charge Plasma TFET with SiGe Pocket

This study proposes a source pocket-based charge plasma TFET with a dual source cavity (DSC-SPCPT) sensor for detecting various cancerous breast cells. A compound SiGe source pocket in the charge plasma TFET offers a higher drain current than TFET as a result of its wider band bending and shorter tunneling length. The breast cells get immobile within the etched nanocavity beneath both source metals. The source cavity's dielectric constant changes with exposure to four tumorigenic breast cells (MCF-7, Hs578T, T47D, and MDA-MB-231) and a healthy cell (MCF-10A). The energy band diagram, threshold voltage, drain current, and transconductance are among the analogue metrics analysed when exposed to malignant cells. This study further estimates the biosensor's sensitivity considering parameters such as drain current, current ratio, transconductance, and threshold voltage, when exposed to both kinds of cells. The proposed sensor is significantly more sensitive to T47D malignant cells in terms of peak drain current (1.03×10 ¹² ), transconductance (3.46×10 ¹¹ ), and current ratio (3.31×10 ⁹ ). This magnitude is more than four decades higher than the result of healthy breast cells. The effects of temperature on the sensitivity performance are also thoroughly examined.