Surface Plasmon Resonance Biosensor for Detection of cortisol with enhance Wavelength Sensitivity: Theoretical analysis

This paper introduces an advanced SPR biosensor utilizing wavelength interrogation to detect varying concentrations of cortisol. The proposed sensor integrates a BAF10 prism, silver (Ag), few layer of transition metal dichalcogenides (TMDCs) and MXene layer, aiming to evaluate sensitivity metrics such as detection accuracy (DA), figure of merit (FoM), wavelength sensitivity (WS), and the limit of detection (LoD). For the measurement of cortisol concentration, the sensor maximum WS is 5000, 5000, 4375 and 4375 nm/RIU using MoS2, MoS2, WS2 and WSe2 layer with remarkable FoM and LoD, respectively. These results were derived via numerical analysis using the finite element method (FEM) formed the foundation of these results. Additionally, 2×10−7 RIU for MoS2, 2×10−7 RIU for MoSe2, 2.28×10−7 RIU for WS2, and 2.29×10−7 RIU for WSe2, are attained the LoD values. 218.64 nm is determined to be the sensor’s penetration depth (PD). According to these results, the proposed SPR sensor might be a quick and efficient method for the detection of various application.