Evaluation of a Grape Extract and Coenzyme Q10-Based Nutricosmetic Formula on Cellulite-Related Parameters

Background Cellulite is a common cosmetic concern in women, associated with alterations in microcirculation, adipocyte hypertrophy, and connective tissue remodeling. Nutricosmetic formulations based on natural extracts may represent a non-invasive option to support long-term skin appearance. Objectives To evaluate the effects of a patented oral formulation (Celluvine™) containing grape extract and coenzyme Q10 on cellulite-related parameters in women under real-world conditions. Methods This real-world study included women aged 30–50 years with a body mass index between 25 and 30 and visible cellulite. Participants consumed one capsule per day (283 mg) for two months, followed by a one-month follow-up without supplementation. Self-assessed parameters (orange peel appearance, water retention, physical complexes, self-confidence, body well-being, sensation of lightness) were rated on a 0–10 scale at baseline, 1 month, 2 months, and after follow-up. Objective measurements (weight, body fat, body circumferences) were performed at baseline and 2 months. Results Forty participants completed the protocol. After two months, significant improvements were reported in orange peel appearance (-22%), water retention (-25%), and physical complexes (-22%). Self-confidence (+ 56%), body well-being (+ 61%), and sensation of lightness (+ 98%) increased in parallel. Objective measures confirmed reductions in body weight (mean − 2.3 kg), body fat (mean − 12.4%), and waist (-5.9 cm), hips (-4.9 cm), and thighs (-4.4 cm) circumference. No adverse effects were reported. Benefits were maintained after the follow-up period. Conclusions Daily intake of the formulation was safe, well tolerated, and associated with measurable improvements in cellulite-related parameters and well-being. Larger placebo-controlled trials are needed to confirm these findings.