A Thiosemicarbazone-Derived Fluorescent Probe For The Detection Of Silver Ions And Bioimaging Application

  1. Arumugam Sreedevi
  2. Gunasekaran Prabhakaran
  3. Nattamai Bhuvanesh
  4. Malathi Mahalingam
  5. Raju Nandhakumar
  6. Gopalan Subashini
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Abstract

A simple thiosemicarbazone-derived ( E )-2-((2-Hydroxynaphthalen-1-yl)Methylene)-N-Methyl-N-Phenylhydrazinecarbothioamide was prepared and characterized using diverse analytical methods and spectroscopic techniques. The definitive elucidation of its crystal structure was achieved through single-crystal X-ray diffraction analysis. The synthesized compound (2NP) was found to be highly specific and sensitive towards sensing silver ions. Time-dependent fluorescence studies of 2NP showed selectivity towards Ag + ion with a detection limit of 5.8995 x 10 − 5 M with a binding constant of 1.7x10 2 M − 1 . The binding stoichiometry of 2NP + Ag complex was further confirmed by Jobs Plot analysis, Benesi-Hidebrand analysis. 1H NMR, ESI-TOF and DFT studies confirmed the formation of [Ag(2NP) 2 ] complex(2:1). Further, the compound 2NP has been tested for its cytotoxicity and bioimaging studies was also performed in Mouse Fibroblast Cell Lines (L929).

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  1. Version published to 10.21203/rs.3.rs-8086522/v1 on Research Square