Biochemical and histological changes in the liver of rat after administration of streptozotocin

Introduction Diabetes is endocrine disorder, which were manifested by experimental animal model by using Streptozotocin (STZ), It damages the liver cell after few months shown the effects on structure of hepatic cell. On the other hand, research tends to investigate with the help of biochemical test such as level of alanine aminotransferase (ALT), aspartate aminotransferase (AST) and alkaline phosphatase (ALP) reveal the damage in liver and histological studies Liver. Materials and methods Experiments were conducted on ten adult male Wistar rats (9–12) weeks of age and 180 ± 30 gm of body weight). There were divided into two groups (n = 10 in each) group Ⅰ (control), group Ⅱ (Diabetic) treated with single dose of STZ (65mg/Kg body weight). Collected the blood and tissue sample for pathologically as well as histological examined of the control and treated rats. Results The analysis of data showed that single high dose STZ treatment cause changes in blood glucose level, body temperature, body weight, different level of changes in enzyme found in liver function test. In liver damage in central vein, blood sinusoid and accumulation of glycogen found in histological slides. Conclusion Histological changes of tissue provide valuable insight into the pathophysiology of diabetes and development of novel therapeutic approaches for disease.