Triglyceride glucose-body mass index is a risk factor for adverse clinical outcomes in patients undergoing septal myectomy: a retrospective study

Background This study investigated whether triglyceride‑glucose‑body mass index (TyG-BMI) is associated with clinical outcomes among individuals undergoing septal myectomy. Methods The retrospective cohort study was conducted at Fuwai Hospital, enrolling 1302 individuals with hypertrophic obstructive cardiomyopathy (HOCM) who received septal myectomy. According to the tertile distribution of TyG-BMI, participants were classified into 3 groups (T1-T3). The primary endpoint consisted of hospitalization attributable to heart failure and overall death. Results Mean age of the participants was 49.2 ± 11.8 years, of whom 61% (791) were men. During the 4.7-year follow-up, both composite endpoints and overall mortality were significantly different across the three groups on the K-M curve (Log-rank P < 0.05). Cox analysis showed patients in group T3 exhibited the greatest incidence rates of primary endpoint (adjusted hazard ratio (HR) = 2.18, 95% confidence interval (CI) 1.24–3.83, P = 0.007), as well as the highest risk of overall death (adjusted HR = 3.67, 95% CI 1.41–9.58, P = 0.008) compared to those in group T1. When treated as a continuous variable, TyG-BMI remained significantly linked to an elevated risk of primary endpoint (each 1-SD increment, adjusted HR = 1.39, 95%CI 1.12–1.71, P = 0.003) and increased overall mortality (each 1-SD increment, adjusted HR = 1.72, 95%CI 1.29–2.30, P < 0.001). Conclusions The observations emphasize the role of TyG-BMI in the prediction of adverse outcomes after septal myectomy in HOCM.